HPE ProLiant ML350 Gen10 is the industry’s most versatile tower server, built for branch offices, remote sites and growing data-centres that need enterprise horsepower without a rack by default. Two Intel® Xeon® Scalable processors (Bronze ➜ Platinum) deliver up to 28 cores per socket, while 24 DIMM slots supply up to 3 TB of 2933 MT/s HPE DDR4 SmartMemory—with optional Persistent Memory for database acceleration.
The redesigned chassis scales effortlessly from 4 LFF to 12 LFF, or from 8 to 24 SFF bays, and even adds up to 8 NVMe drives for latency-critical workloads. Eight PCIe Gen3 slots accept GPUs, NICs and HBAs, and a rail kit converts the 4U tower into a 5U rack server whenever your facility grows.
| SKU | CPU / Memory | Drive Bays | Controller | PSU | Tier / Form |
|---|---|---|---|---|---|
| 877619-AA1 | Bronze 3104 • 1 P • 8 GB | 4 LFF (NHP) | S100i SATA RAID | 1 × 500 W | Sub-Entry • Tower 4U |
| 877620-AA1 | Bronze 3106 • 1 P • 16 GB | 4 LFF (hot-swap) | S100i SATA RAID | 1 × 500 W FS RPS | Entry • Tower 4U |
| 877621-AA1 | Silver 4110 • 1 P • 16 GB | 8 SFF | P408i-a 2 GB SAS RAID | 1 × 800 W FS RPS | Base • Tower 4U |
| 877625-B21 | 0 CPU • 0 GB (CTO) | 4 LFF | S100i (upgradeable) | None (CTO) | CTO • Tower 4U |
| 877626-B21 | 0 CPU • 0 GB (CTO) | 8 SFF | S100i (upgradeable) | None (CTO) | CTO • Tower 4U |
| 877627-B21 | 0 CPU • 0 GB (CTO) | 8 SFF | S100i (upgradeable) | None (CTO) | CTO • Rack 5U |
Up to two Intel Xeon Scalable CPUs, 24 DIMMs of 2933 MT/s DDR4 and optional Persistent Memory give the ML350 Gen10 the raw compute and in-memory analytics power normally reserved for high-end rack servers.
Silicon Root of Trust validates firmware during every boot and re-checks it every 24 hours. Secure Recovery can roll back to a known-good image, while optional TPM 2.0, chassis intrusion sensors and a locking bezel guard physical and logical access.
HPE Pointnext Advisory, Professional and Operational Services streamline deployment and keep the platform running with options such as Flexible Capacity and Datacenter Care.
| Processor Family | Intel® Xeon® Scalable 8100 / 6100 / 5100 / 4100 / 3100 Series |
|---|---|
| Sockets | 1 or 2 (model dependent) |
| Cores per CPU | 4 – 28 cores |
| Max Memory | 3 TB (24 × 128 GB DDR4 2933) · up to 192 GB HPE Persistent Memory |
| DIMM Slots | 24 DDR4 RDIMM/LRDIMM |
| Drive Bays | 4 – 12 LFF (SAS/SATA) | 8 – 24 SFF (SAS/SATA) | up to 8 SFF NVMe |
| Expansion Slots | 8 × PCIe Gen3 (4 × x16, 4 × x8) |
| GPU Support | Up to 4 single-wide or 2 double-wide GPUs |
| Network | Embedded 4 × 1 GbE 369i | Optional 1/10/25/40 GbE PCIe or FlexibleLOM |
| Form Factor | 4U Tower · Convertible to 5U Rack |
| Power Supplies | 500 W / 800 W / 1600 W HPE Flexible Slot (redundant) or 500 W non-RPS |
| Fans | 2 standard (non-hot-plug) · optional 4 hot-plug for N+1 |
| Dimensions (H × D × W) | 18.2 × 25.51 × 6.85 in (462 × 648 × 174 mm) |
| Weight | 46.3 lb (21 kg) bare minimum |
| Management | iLO 5 Standard with Intelligent Provisioning | Optional iLO Advanced / OneView |
| Security Options | TPM 2.0, locking bezel, Kensington & padlock slots, chassis intrusion sensor |
Our lightning-fast online configurator lets you build a custom HPE ProLiant ML350 Gen10 in seconds—select CPUs, memory, drives, GPUs and NICs from the full QuickSpecs catalogue and receive an instant quote. Every order is double-checked by our technical team to guarantee component-level compatibility, so you can focus on workloads, not parts lists.
The ML350 Gen10 supports the complete Intel Xeon® Scalable family in single- or dual-socket mode:
All SKUs benefit from 24 DIMM slots (up to 3 TB), eight PCIe Gen3 slots, GPU enablement and flexible drive backplanes.
Dual high-core CPUs, 24 DIMMs and multiple drive cages fit into a quiet 4U chassis that slides into a 5U rack kit when your office outgrows the server room.
Whether you need dense virtualisation hosts, capacity-heavy backup targets or GPU-accelerated VDI nodes, ML350 Gen10 scales seamlessly to match your performance and storage goals.
The HPE ML350 Gen10 4 LFF Tower is a dual-socket platform that scales to two Intel® Xeon® Scalable processors and up to 3 TB (24 × 128 GB) of DDR4 2933 RDIMM memory. Three PCIe Gen3 expansion slots are available.
Large-form-factor (3.5 in) drives deliver higher capacity at a lower $/TB than SFF, making this variant ideal for bulk storage, backup or video surveillance.
The HPE ML350 Gen10 8 SFF Tower is also a dual-socket system (two Intel® Xeon® Scalable CPUs max) with support for 24 RDIMMs at 2933 MT/s and three PCIe Gen3 slots.
Small-form-factor (2.5 in) hot-swap bays pack more spindles or SSDs into the same chassis footprint and are typically more power-efficient than 3.5-in drives—perfect for mixed flash/HDD arrays or dense VM workloads.
